
2026-09-25 · Japan
Target engagement is not the same as benefit
Human randomized trialBlood NAD metabolites; hearing and physical-performance outcomes.
npj Aging↗
Target engagement alongside a null primary outcome.

The negative functional finding remains visible rather than being displaced by a positive biochemical signal.

Blood NAD metabolites; hearing and physical-performance outcomes.
Not a comprehensive national literature review. Study location or lead-affiliation context is used for navigation, not to imply a partnership, local facility, or regulatory status.