From a paper to a testable program

Identify the decisive uncertainty

A mechanism can be interesting while its practical value remains unclear. State the one uncertainty that blocks the next decision, then select measurements that could resolve it.

Set advance and stop conditions

Define what would justify another experiment and what would require a change in direction. These conditions should include safety and alternative explanations, not merely a desired effect size.

Keep the evidence trail intact

Record the source, access level, exact model, endpoint, limitations, and what Karam has actually done. External results remain external results even when they inform an internal research direction.