Function before an age number

Name the job first

Before choosing an assay, write down what the tissue should do better. The answer might be a reproducible performance measure, a repair outcome, or a specific cellular task. Avoid choosing the definition of success after seeing which marker changes.

Preserve separate outcomes

Record target engagement, molecular state, cell identity, and tissue performance separately. A positive finding in one category must not erase a null result in another. The separation also makes disagreements more informative.

Make the next decision explicit

A useful brief ends with the missing observation that would change the decision. It should not end with an impressive percentage detached from its population, assay, and comparator.