The source trail stays visible.

Yin J, Gao Y, Jing Y, et al. CRISPR screening identifies GNPTAB as a noncanonical STING activator driving cellular senescence. Protein & Cell. 27 July 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Chen ACY, Ji KY, Yerinde C, et al. CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer. Cell. 29 July 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Plesa AM, Jung S, Wang HH, et al. Transcriptomic reprogramming screen identifies SRSF1 as a regulator of aging. Nature Aging. 14 October 2026;6:2057–2073.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Yu T, Ji M, Yu D, et al. Structure-guided discovery and engineering of miniature CRISPR–Cas12m for epigenome editing. Nature Structural & Molecular Biology. 16 September 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Hsu A, Chen PJ, Li AH, et al. Mechanistic machine learning for prediction of prime editing outcomes. Nature Biotechnology. 12 August 2026.

Publisher code-availability statement checked on 15 October 2026. It describes OptiPrime code and hosted service as noncommercial-use only.

Madsen A, Selfjord N, Martinez-Lage M, et al. Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes. Nature Communications. 26 August 2026;17:9067.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Hwang GH, Vyshedskiy B, Barry T, et al. Analysing long-read CRISPR experiments with CRISPRLungo. Nature Biomedical Engineering. 20 August 2026.

Author-laboratory publication abstract, repository and browser-tool page located on 15 October 2026; no independent software performance test.

Jung H, Devant P, Ching C, et al. Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells. Nature Biotechnology. 17 August 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Jung H, Jeong B, Kim YW, et al. Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing. Nature Biotechnology. 28 August 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Gu D, Kim GWD, Park M, et al. Abasic CRISPR RNAs inherently harness fidelity of SpCas9 for genome editing. Nature Chemical Biology. 5 February 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Saroj N, Velangani HG, Kiran S, Dholaniya PS. Deletion of TOP2B promoter using CRISPR-Cas9 induces senescence in HEK 293T cells. Biochemistry and Biophysics Reports. 19 May 2026;46:102620.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Lai C, Fu W, Liu J, et al. LMO7-mediated POLR2A degradation promotes cellular senescence through the MDM4/p53/p21 axis. Cell Death & Disease. 28 March 2026;17:421.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Burr SP, Auckland K, Glynos A, et al. MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy. Nature Structural & Molecular Biology. 1 April 2026;33:711–723.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Jiang AY, Cristian A, Brooks DL, et al. Efficient prime editing in vivo and in vitro using lipid nanoparticles. Nature Nanotechnology. 15 June 2026;21:1022–1035.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Laffin LJ, Nicholls SJ, Scott RS. Durability of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 with CTX310. New England Journal of Medicine. Online 28 August 2026;395:1343–1345.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Life Biosciences. First-in-human data from the ongoing Phase 1 trial of ER-100 in optic neuropathies. Sponsor announcement. 8 October 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

US Food and Drug Administration. FDA Approves First Gene Therapy for Young Children with Sickle Cell Disease. FDA announcement. 1 July 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Intellia Therapeutics. FDA lift of clinical hold on MAGNITUDE Phase 3 clinical trial in ATTR-CM. Sponsor announcement. 2 March 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

US Food and Drug Administration. Safety Assessment of Genome Editing in Human Gene Therapy Products Using Next-Generation Sequencing. Draft guidance. April 2026.

FDA guidance landing page checked on 15 October 2026: marked Draft, not for implementation, nonbinding.

ClinicalTrials.gov; Life Biosciences sponsor record. Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy. NCT07290244. Reviewed 15 October 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Broad Institute. Licensing gene editing systems. Current institutional policy reviewed 15 October 2026; administrative context.

Broad Institute licensing policy page checked on 15 October 2026. This is one licensor’s policy, not a complete freedom-to-operate opinion.

Henard JM, Lee SA, Yu YC, Shao D, Azad RK, Henard CA. CRISPRi-based functional genomic screening identifies genes essential for CH4-dependent growth in a methanotrophic bacterium. Science Advances. 24 April 2026;12:eaed4234.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Groover ED, Ding D, Wang FZ, et al. Mapping cis-regulatory mutations at scale in sorghum enables modulation of gene expression. Nature Biotechnology. 27 March 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Shi LD, Ercoli MF, Kim J, et al. Reduced methane emissions in transgenic rice genotypes are associated with altered rhizosphere microbial hydrogen cycling. Nature Communications. 26 January 2026;17:2028.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Wang Z, Wang S, Yue Z, et al. WLG coordinates multi-stress tolerance in rice by regulating DST-dependent H2O2 homeostasis and stomatal aperture. Nature Communications. 16 September 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Chang J, Wang D, Yao Z, et al. Wild rice locus enables microbiome re-domestication for enhanced nitrogen-use efficiency. Nature Microbiology. 30 September 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Yamori W, Nakazato I, Qu Y, et al. Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth. Nature Communications. 19 June 2026;17:5066.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Innovative Genomics Institute. Support from Google.org for AI science research on microbiomes and agricultural methane. Institutional research announcement. 26 January 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

National Institutes of Health. Notice of Revisions to the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules. NOT-OD-24-093. 4 April 2024; effective 30 September 2024. Established governance context.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

World Health Organization. Guidance framework for testing of genetically modified mosquitoes, second edition. 19 May 2021. Established guidance, not a 2026 research result.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Feng X, Ding J, Liu Y, et al. Self-limiting population suppression gene drive design in the West Nile vector mosquito, Culex quinquefasciatus. Nature Communications. First published 26 May 2026;17:6847.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Kim IK, Tian L, Chaffee R, et al. Seed dormancy shapes gene drive dynamics in plants. Nature Plants. 3 April 2026;12:735–749. Modeling study.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Target Malaria. Common questions about gene drive, answered. Developer statement. 30 March 2026; status claims are specific to that date.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

The Royal Society. Genetic technologies. Institutional overview reviewed 15 October 2026; proposed applications, not field validation.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Symons TL, Moran A, Balzarolo A, et al. Projected impacts of climate change on malaria in Africa. Nature. 28 January 2026;651:390–396. Modeling study.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Maull V, Aguadé-Gorgorió G, de Lorenzo V, Solé R. Synthetic horizontal gene transfer for ecosystem restoration. Biology Direct. 14 August 2026. Accepted article; theoretical modeling.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Esvelt KM, Smidler AL, Catteruccia F, Church GM. Concerning RNA-guided gene drives for the alteration of wild populations. eLife. 2014;3:e03401. Foundational proposal, not recent deployment evidence.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

US Food and Drug Administration. Myths about Cloning. Institutional explanation reviewed 15 October 2026. Primarily livestock context.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

ViaGen Pets. How To Clone A Dog: What to Expect & Do Before You Commit. Commercial provider explanation reviewed 15 October 2026; not an independent efficacy evaluation.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

ViaGen Pets. Can you clone a dog after death? Commercial provider explanation reviewed 15 October 2026; sample feasibility is case-specific.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

US Food and Drug Administration. A Primer on Cloning and Its Use in Livestock Operations. Established SCNT explanation reviewed 15 October 2026; livestock findings are not pet-specific success rates.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Death X. Personal Biological & Digital Archive. Live project page reviewed 15 October 2026; published program edition 14 October 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Death X. Living Cell Banking & Personal Cell Archives. Project proposal published 14 October 2026; reviewed 15 October 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Death X. The Archive & Continuation Research. Live project options reviewed 15 October 2026; Culture remains a contained research concept.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.

Death X. 14 Research Directions for Biological Continuation. Project opportunity map reviewed 15 October 2026.

Cited in the supplied 15 October 2026 project assessment; not independently reviewed in this website release.